Abstract
Hyaluronic acid (HA) yog biodegradable, biocompatible, nontoxic, thiab non-immunogenic glycosaminoglycan siv rau ntau daim ntaub ntawv biomedical. Kev sib koom tes ntawm HA nrog CD44 reseptor, uas qhia tau hais tias yog siab ntawm ntau hom qog hlwb, ua rau cov neeg muaj peev xwm ua rau cov tub ntxhais kawm ntawv muaj peev xwm thiab cov neeg ua haujlwm rau cov neeg ua haujlwm siv lub tswv yim zoo. Yog li ntawd, HA thiab nws cov derivatives tau raug tshawb fawb feem ntau rau txoj kev loj hlob ntawm ntau hom kab mob kev lag luam rau kev mob cancer thiab kev kho mob. Txawm li cas los xij, kev siv cov ntaub ntawv sib txawv thiab tseem ceeb ntawm tus mob polysaccharide kuj tau piav qhia, xws li cov noob thiab cov peptide / cov tshuaj protein. Lub hom phiaj ntawm kev txheeb xyuas no yog los muab cov ntsiab lus tseem ceeb ntawm cov ntaub ntawv nyuam qhuav nyuam qhuav dhau los ntawm kev siv HA thiab nws cov dej num rau kev siv tshuaj thiab kev kuaj pom. Notable xim muab rau nanotheranostic systems tau tom qab conjugation ntawm HA rau nanocarriers li quantum dots, carbon nanotubes thiab graphene. Lub caij no, tseem ceeb rau qee yam kev nyuaj uas yuav tsum tau hais rau kom thiaj li tso cai txhais lus ntawm cov qauv tshwj xeeb raws li HA thiab nws txoj kev siv tshuaj rau kev siv yeeb tshuaj thiab kev mus tshuaj ntsuam xyuas thiab soj ntsuam ntxiv.
